Sildenafil vs. tadafil
Sildenafil vs Tadalafil – Which is Better for ED?

Sildenafil (commonly known as Viagra) and tadalafil (often prescribed as Cialis) are widely used ED medications to address erectile dysfunction (ED) effectively. 

PDE5 inhibitor is the active ingredient in both drugs, both drugs interact with the body’s natural chemicals released during arousal, causing relaxation of the smooth muscle in the penis. This, in turn, promotes increased blood flow to the penis, facilitating the achievement of a firm erection. 

In this comprehensive guide, we’ll provide valuable insights into sildenafil vs. tadalafil, enabling you to make an informed decision and find the best-personalized treatment for ED tailored to your specific needs.

Top Differences: Sildenafil vs Tadalafil

The difference between sildenafil and tadalafil lies in terms of effectiveness, working, and other aspects. Let’s take a

look. Sildenafil introduced in 1998, and tadalafil, introduced in 2003, are medications commonly used to treat erectile dysfunction (ED). 

  • However, tadalafil offers an additional benefit as it can also address an enlarged prostate (BPH), making it particularly advantageous for older patients or those suffering from both conditions.

  • While sildenafil must be taken approximately 60 minutes before sexual activity, with only one dosage per day, tadalafil provides more flexibility.

  • Tadalafil can be taken either 60 minutes before intercourse or taken regularly, allowing for more spontaneity in sexual encounters. Furthermore, tadalafil’s effects may last up to 36 hours, significantly longer than sildenafil, making it a preferred choice for some individuals.

  • It’s important to note that tadalafil’s extended duration of action means any potential side effects may last longer as well, making sildenafil a preferable option for men sensitive to medication effects.

Both drugs have shown high effectiveness in treating ED, with nearly 70% of men experiencing improved erection quality

Additionally, tadalafil has demonstrated positive effects on urinary symptoms in some men. If you are thinking about, tadalafil or sildenafil which is better? Then, it depends on what works better for you. You can experiment with both medicines. And attentively observe the effects and opt for what works better for you. 

Tadalafil vs Sildenafil Dosage

Now let’s take a look at tadalafil vs sildenafil dosage. We have developed a table for better reference. 


DrugRecommended DosageMaximum Daily DosageDosage Forms
Sildenafil25mg to 100mg, depending on the case100mg for all ages20mg (Generic), 25mg, 50mg, 100mg
TadalafilAverage: 10mg per dayUp to 20mg per day, as needed2.5mg, 5mg, 10mg, 20mg

For Sildenafil:

  • It can be taken once daily, it is preferred to take Sildenafil one hour before intercourse.
  • A doctor may start with a lower dosage to minimize side effects.
  • If the desired effects are not achieved, the doctor will guide when and how to increase the dosage, up to a maximum of 100mg per day.

For Tadalafil:

Tadafil medicine

  • The average daily dosage is 10mg, but doctors may prescribe anywhere from 5mg to 20mg depending on the patient’s situation.
  • Daily dosing of 5mg is possible, and for some, older patients, smaller doses every other day may be recommended.
  • For on-demand usage, 5mg, 10mg, or 20mg take tadalafil one hour before one hour of intercourse.

Tadalafil vs Sildenafil Side Effects

Refer to the below table to learn about tadalafil vs sildenafil side effects.  

Side EffectsSildenafil (Viagra)Tadalafil (Cialis)
CommonHeadache, Indigestion, Blurred vision, Nausea, Dizziness, Light sensitivity, Nasal congestion, RashHeadache, Back pain, Indigestion, Dizziness, Nausea, Blurred vision, Rash
Rare but SeriousIncreased risk of stroke or heart attack, Low blood pressure, Hearing loss, Medication interactionsIncreased risk of heart attack or stroke, Low blood pressure, Hearing loss, Medication interactions
Priapism (emergency situation), can lead to permanent tissue damage or amputationPriapism (emergency situation), can lead to permanent tissue damage or amputation


Read More: 7 Easy Exercises for Stronger Erections and Erectile Dysfunction


Common Side Effects: Tadalafil vs Sildenafil Dosage

Both Sildenafil (Viagra) and Tadalafil (Cialis) are known to increase circulation and, as a result, have similar side effects such as headache, nausea, dizziness, and more. It’s crucial to avoid using either medication if you’ve had a stroke, heart attack, or other vascular issues in the past six months. One noticeable side effect difference is that sildenafil may cause bluish vision, while tadalafil is more likely to cause low back discomfort.


Sildenafil medicine

For Sildenafil, some common side effects include headache, indigestion, blurred vision, and rash, while more serious but rare effects include an increased risk of stroke or heart attack, low blood pressure, and hearing loss. Priapism, an emergency situation where an erection lasts for more than four hours, requires immediate medical attention.


For Tadalafil, common side effects include headache, back pain, indigestion, and rash, while serious but rare complications encompass increased risk of heart attack or stroke, low blood pressure, and hearing loss. 

Sildenafil Vs Tadalafil For Erectile Dysfunction

Let’s take a look at Sildenafil Vs Tadalafil on three different aspects. These are as follows:

  1. Is Tadalafil Better than Sildenafil? 
  2. Comparison of Tadalafil and Sildenafil Onset Time

Is Tadalafil Better than Sildenafil?

Potency for EDBoth medications offer similar benefits but many prefer Tadalafil due to its popularity.  Both medications offer similar benefits

Some individuals may react better to Sildenafil medication than the other

Sildenafil may be less potent when taken immediately after a meal

Stomach ImpactCan be taken on an empty or full stomachWorks best on an empty stomach

Eating before taking may decrease the response

Duration of ActionEffects may last up to 36 hoursGenerally lasts 6-8 hours after one dose

Younger men may feel effects for up to 24

Comparison of Tadalafil and Sildenafil Onset Time

Onset TimeAround 30-60 minutesAround 30-60 minutes
Best AdministrationSome experience effect in 30 minutes, while others may take 2 to 12 hourswork best on an empty stomach, take 30 minutes before eating or 2 hours after Eating or drinking prior to taking slows absorption and decreases response


Ending Statement 

Hope now have now learned about sildenafil vs tadalafil. Both Sildenafil and Tadalafil are safe and efficient in improving the erection of penile muscles during sexual stimulation, with high success rates comparable to brand drugs. They share similar side effects, making them almost equal except for the duration of the effects. Additionally, their affordability makes them excellent choices for treating erectile dysfunction.