Doxycycline Hyclate 100 mg Tablet


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Doxycycline Hyclate 100 mg Tablet, is a type of antibiotic known as tetracycline, which is utilized to combat various infections caused by specific types of bacteria. Additionally, it is employed for the treatment and prevention of anthrax (a severe infection that can be intentionally spread in bioterror attacks) in individuals who may have been exposed to anthrax in the air. Moreover, doxycycline hyclate 100 mg tablet is used to address cases of plague and tularemia (serious infections that may be spread intentionally as part of bioterror attacks). It is also employed as a preventive measure against malaria.

What is Doxycycline Hyclate?

Doxycycline hyclate is a salt form of doxycycline, which is a broad-spectrum antibiotic belonging to the tetracycline class. Doxycycline hyclate is derived from doxycycline by combining it with hydrochloric acid to form a salt. It is commonly used in pharmaceutical formulations as it has enhanced stability and better solubility compared to the base form of doxycycline.

Doxycycline hyclate has the same medicinal properties and uses as doxycycline. It is utilized to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin infections, sexually transmitted infections, eye infections, and certain types of tick-borne illnesses like Lyme disease. It is also employed for the prevention and treatment of malaria.

As with doxycycline, doxycycline hyclate should only be used under the guidance of a healthcare professional and should not be used to treat viral infections such as colds or the flu. Adherence to prescribed dosages and completing the full course of treatment is important to ensure the effectiveness of the medication.

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How Doxycycline Tablet Works?

Doxycycline tablets work by inhibiting the growth and spread of bacteria in the body. As a member of the tetracycline class of antibiotics, doxycycline exerts its action through multiple mechanisms.

Firstly, doxycycline interferes with the ability of bacteria to produce proteins necessary for their growth and replication. It does this by binding to the bacterial ribosomes, which are responsible for protein synthesis. By binding to the ribosomes, doxycycline prevents the attachment of amino acids and blocks the formation of new proteins, hindering bacterial growth.

Secondly, doxycycline inhibits the activity of an enzyme called bacterial DNA gyrase. DNA gyrase plays a crucial role in the replication and repair of bacterial DNA. By inhibiting this enzyme, doxycycline interferes with bacterial DNA synthesis, further impeding bacterial growth and replication.

Additionally, doxycycline has anti-inflammatory properties that can contribute to its therapeutic effects in certain conditions. It can help reduce inflammation associated with conditions like acne and rosacea, which involve inflammatory processes in the skin.

It is important to note that doxycycline specifically targets bacteria and is not effective against viral infections. It is crucial to take doxycycline as prescribed by a healthcare professional and complete the full course of treatment to ensure the most effective eradication of bacterial infections.

Doxycycline 100mg Uses

Doxycycline is available in different forms such as capsules, tablets, delayed-release tablets, and suspension (liquid) for oral consumption. It is typically taken once or twice a day, accompanied by a full glass of water. If doxycycline upsets your stomach, you may take it with food or milk, but it’s advisable to consult your doctor or pharmacist for the best approach. Follow the instructions on your prescription label carefully, and seek clarification from your healthcare provider if needed. Adhere to the prescribed dosage and schedule, without taking more or less of it or altering the frequency of administration.

Delayed-release tablets should be swallowed whole without splitting, chewing, or crushing them. In case you have difficulty swallowing specific delayed-release tablets (such as Doryx or generic equivalents), you can carefully break up the tablet and sprinkle the contents onto a spoonful of cold or room temperature (not hot) applesauce. Take caution not to crush or damage the pellets while breaking up the tablet. Consume the mixture immediately without chewing, or if not feasible, discard it.

Before each use, shake the suspension well to ensure the even distribution of the medication.

If you are taking doxycycline for malaria prevention, begin the treatment 1 or 2 days prior to traveling to a malaria-prone area. Continue taking doxycycline daily while you remain in the area and for 4 weeks after leaving. The duration of using doxycycline for malaria prevention should not exceed 4 months.

Even if you start feeling better, continue taking the complete course of doxycycline as prescribed, unless instructed otherwise by your doctor.

It’s important to note that different doxycycline products may not be interchangeable. Ensure that you receive the specific type of doxycycline prescribed by your doctor. If you have any questions about the doxycycline you were provided, consult your pharmacist for clarification.


The dosage of this medication varies for each individual and is determined by your doctor’s instructions or the guidelines on the label. The information provided here presents average doses of this medicine. Do not alter your dose unless specifically directed by your doctor.

The quantity of medicine you take is influenced by the potency of the medication. Additionally, the frequency of daily doses, the intervals between doses, and the duration of treatment depend on the specific medical condition being addressed with the medicine.

Many factors can influence doxycycline 100mg tablets price, including brand, dosage form, and quantity, so it’s wise to shop around for the best deal.

When considering your healthcare options, it’s essential to compare doxycycline 100mg price variations from different suppliers to make an informed decision.

Missed Dose:

If you happen to forget a dose of Doxycycline Hyclate Tablet, promptly take it as soon as you recall. However, if it is nearing the time for your next scheduled dose, it is advisable to skip the missed dose and continue with your regular dosing schedule. Taking a double dose to make up for the missed one should be avoided to prevent potential complications.


In the event of a suspected doxycycline overdose or accidental ingestion of more doxycycline tablets than prescribed, it is essential to treat the situation seriously and seek urgent medical assistance or contact your local poison control center. An overdose of doxycycline can have potential adverse effects on your health. Symptoms that may indicate an overdose include severe nausea, vomiting, abdominal pain, dizziness, confusion, blurred vision, heightened sensitivity to light, and fainting. Prompt medical attention is necessary to ensure appropriate care and management in such situations.

In the case of an overdose, medical professionals will evaluate your condition, provide supportive care, and take appropriate measures to manage the overdose effects. This may involve measures to remove the excess doxycycline from your body, such as inducing vomiting or administering activated charcoal. Treatment will focus on alleviating symptoms and maintaining vital signs while ensuring the best possible outcome.

It is important to always adhere to the prescribed dosage of doxycycline and to promptly seek medical advice if you have any concerns or questions regarding your medication.

Important Advisory of Doxycycline Hyclate Tablet

  • Notify your doctor and pharmacist if you have any allergies, including allergies to doxycycline, minocycline, tetracycline, demeclocycline, sulfites, or any ingredients in doxycycline products. It is recommended to consult your pharmacist for a comprehensive list of ingredients.
  • Inform your doctor and pharmacist about all the prescription and non-prescription medications, vitamins, and supplements you are currently taking or plan to take. Be sure to mention medications such as acitretin, anticoagulants like warfarin, bismuth subsalicylate, carbamazepine, isotretinoin, penicillin, phenobarbital, phenytoin, and proton pump inhibitors. Your doctor may need to adjust your medication dosages or monitor you closely for any potential side effects. If your doctor prescribes doxycycline, you can easily buy doxycycline 100mg from reputable pharmacies, ensuring you receive the treatment you need at a competitive price.
  • Please note that specific antacids containing magnesium, aluminum, or calcium, along with calcium supplements, iron products, and laxatives containing magnesium, can potentially affect the effectiveness of doxycycline. For optimal absorption, it is recommended to take doxycycline either 1-2 hours before or after consuming antacids, calcium supplements, or magnesium-containing laxatives. Additionally, take doxycycline 2 hours before or 3 hours after consuming iron preparations and vitamin products that contain iron to ensure proper absorption and effectiveness.
  • Inform your doctor if you have a history of lupus, intracranial hypertension, yeast infections in the mouth or vagina, stomach surgery, asthma, kidney or liver disease, or if you experience diarrhea. Additionally, inform your doctor if you are currently using hormonal contraceptives, as doxycycline may decrease their effectiveness. Your doctor can recommend alternative birth control methods.
  • It is essential to inform your healthcare provider if you are currently pregnant or if you have plans to conceive. Keeping your doctor informed about your pregnancy status is crucial for appropriate medical guidance and ensuring the safety of both you and your baby. If you become pregnant while taking doxycycline, contact your doctor immediately, as the medication can harm the fetus.
  • Inform your doctor if you are breastfeeding, as doxycycline may pass into breast milk and affect the nursing infant. Your doctor will advise you on whether to continue breastfeeding during doxycycline treatment.
  • Avoid unnecessary or prolonged exposure to sunlight and protect your skin with clothing, sunglasses, and sunscreen while using doxycycline. Doxycycline can increase sensitivity to sunlight, so promptly notify your doctor if you experience sunburn.
  • When taking doxycycline for malaria prevention, it is essential to employ additional protective measures such as using effective insect repellent, and mosquito nets, wearing clothing that covers the entire body, and staying in well-screened areas, especially from early evening until dawn. Doxycycline alone does not provide complete protection against malaria.
  • Please be mindful that the use of doxycycline during pregnancy or in children up to 8 years of age can result in permanent discoloration of the teeth and may impact proper bone growth. It is crucial to avoid administering doxycycline to children under the age of 8 unless it is specifically prescribed by a doctor for conditions such as inhalational anthrax, Rocky Mountain spotted fever, or based on the medical judgment of a healthcare professional.

Side Effects of Doxycycline Hyclate Pills

Doxycycline usage can lead to various side effects. Please make sure to inform your doctor if any of the following symptoms are severe or persist:

  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Rectal itching
  • In some cases, doxycycline use may cause symptoms such as swelling, redness, burning, itching, or irritation of the vagina. If you experience any of these vaginal discomfort symptoms while taking doxycycline, it is recommended to promptly inform your healthcare provider for further evaluation and guidance.
  • Vaginal discharge
  • Painful or difficult urination
  • Sore throat or nasal discomfort
  • Swollen tongue
  • Dry mouth
  • Anxiety
  • Back pain
  • Changes in skin, scars, nails, eyes, or mouth coloration

Certain side effects may be serious. Contact your doctor without delay if you encounter any of the subsequent symptoms:

  • Headache
  • Please be aware that in some cases, the use of doxycycline may be associated with potential side effects affecting vision, such as blurred vision, double vision, or even vision loss. If you experience any changes in your vision while taking doxycycline, it is important to seek immediate medical attention. Your doctor will be able to evaluate the situation and provide appropriate guidance.
  • If you experience a rash accompanied by fever or swollen glands while taking doxycycline, it is important to seek immediate medical attention. This combination of symptoms may indicate a potentially serious reaction that requires prompt evaluation and appropriate medical intervention.
  • Hives
  • Skin redness, peeling, or blistering
  • Difficulty breathing or swallowing
  • Please note that if you experience swelling of the eyes, face, throat, tongue, or lips while taking doxycycline, it could be a serious allergic reaction. In such cases, it is essential to seek immediate medical attention to ensure appropriate evaluation and treatment.
  • Unusual bleeding or bruising
  • Watery or bloody stools, stomach cramps, or fever during or after treatment (up to two or more months)
  • Return of fever, sore throat, chills, or signs of infection
  • Joint pain
  • Discoloration of permanent (adult) teeth

Doxycycline may also cause other side effects. Contact your doctor if you experience any unusual issues while taking this medication.

Other Drug Interactions with Doxycycline Tablets

Drug interactions can have an impact on the effectiveness of your medications or increase the risk of serious side effects. This information does not cover all possible drug interactions. It is important to maintain a comprehensive list of all products you use, including prescription/nonprescription drugs and herbal products, and share it with your doctor and pharmacist. Do not initiate, discontinue, or alter the dosage of any medication without your doctor’s approval.

Certain products may interact with this medication, including retinoid medications taken orally (such as acitretin, and isotretinoin), barbiturates (such as phenobarbital), “blood thinners” (such as warfarin), digoxin, anti-seizure medications (such as phenytoin), and strontium.

This medication may interfere with specific laboratory tests, potentially leading to inaccurate results. It is essential for laboratory personnel and all your healthcare providers to be aware of your use of this drug.

Some medicines can affect the functioning of Doxy-100 tablets, or Doxy-100 itself may reduce the effectiveness of other medications taken concurrently. Inform your doctor about all the medicines, supplements, or herbal products you are currently taking or may take to avoid potential interactions. This is especially important if you are taking medications for high blood pressure, heart failure, abnormal cholesterol levels, blood thinners, anti-infectives, anti-diabetic medications, anti-asthmatics, painkillers, immunomodulatory medicines, or medications for brain-related disorders.

Oral contraceptives and blood thinners like warfarin can increase the risk of bleeding. Anti-acne medications like isotretinoin can lead to elevated pressure within the brain.

Storage Instructions

Ensure proper storage of this medication by keeping it in the original container, tightly closed, and out of the reach of children. Store it at room temperature, away from light, excess heat, and moisture (avoid storing it in the bathroom).

It is crucial to prevent children from accessing medication, as many containers, such as weekly pill organizers or those for eye drops, creams, patches, and inhalers, may not be child-resistant and can be easily opened by young children. To safeguard against accidental poisoning, always secure safety caps and promptly place medications in a secure location, out of sight and reach of children.

Disposal of unneeded medications should be done in a manner that ensures they cannot be consumed by pets, children, or other individuals. However, it is important not to flush this medication down the toilet. The recommended method of disposal is through a medicine take-back program. Consult your pharmacist or contact your local garbage/recycling department to inquire about available take-back programs in your community.


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